State and location dependence of action potential metabolic cost (Hallermann et al., 2012)

With this model of a layer 5 pyramidal neuron the state and location dependence of the ATP usage and the metabolic efficiency of action potentials can be analyzed. Model parameters were constrained by direct subcellular recordings at dendritic, somatic and axonal compartments.

Model Type: Neuron or other electrically excitable cell

Region(s) or Organism(s): Neocortex

Cell Type(s): Neocortex L5/6 pyramidal GLU cell

Currents: I Na,t; I K

Model Concept(s): Action Potential Initiation; Action Potentials

Simulation Environment: NEURON

Implementer(s): Hallermann, Stefan [hallermann at medizin.uni-leipzig.de]; Kole, Maarten [m.kole at nin.knaw.nl]

References:

Hallermann S, de Kock CP, Stuart GJ, Kole MH. (2012). State and location dependence of action potential metabolic cost in cortical pyramidal neurons. Nature neuroscience. 15 [PubMed]