The authors investigate the transition between sleep and awake states with intracellular recordings in cats and computational models. The model describes many essential features of slow wave sleep and activated states as well as the transition between them.
Model Type: Realistic Network
Region(s) or Organism(s): Thalamus
Cell Type(s): Thalamus geniculate nucleus/lateral principal GLU cell; Thalamus reticular nucleus GABA cell; Neocortex L5/6 pyramidal GLU cell
Currents: I Na,t; I L high threshold; I T low threshold; I K,leak; I M; I K,Ca
Receptors: GabaA; GabaB; AMPA; NMDA
Model Concept(s): Oscillations; Synchronization; Spatio-temporal Activity Patterns; Short-term Synaptic Plasticity; Depression; Sleep
Simulation Environment: C or C++ program
Implementer(s): Bazhenov, Maxim [Bazhenov at Salk.edu]
References:
Bazhenov M, Timofeev I, Steriade M, Sejnowski TJ. (2002). Model of thalamocortical slow-wave sleep oscillations and transitions to activated States. The Journal of neuroscience : the official journal of the Society for Neuroscience. 22 [PubMed]