A unified thalamic model of multiple distinct oscillations (Li, Henriquez and Fröhlich 2017)

We present a unified model of the thalamus that is capable of independently generating multiple distinct oscillations (delta, spindle, alpha and gamma oscillations) under different levels of acetylcholine (ACh) and norepinephrine (NE) modulation corresponding to different physiological conditions (deep sleep, light sleep, relaxed wakefulness and attention). The model also shows that entrainment of thalamic oscillations is state-dependent.

Model Type: Realistic Network

Region(s) or Organism(s): Thalamus

Cell Type(s): Thalamus geniculate nucleus/lateral principal GLU cell; Thalamus reticular nucleus GABA cell; Thalamus lateral geniculate nucleus interneuron

Currents: I Na,t; I K; I h; I L high threshold; I T low threshold; I_AHP; I CAN; I K,leak

Receptors: AMPA; NMDA; GabaA

Transmitters: Acetylcholine; Norephinephrine

Model Concept(s): Sleep; Activity Patterns; Gamma oscillations; Oscillations; Brain Rhythms

Simulation Environment: C or C++ program

Implementer(s): Li, Guoshi [guoshi_li at med.unc.edu]


Li G, Henriquez CS, Fröhlich F. (2017). Unified Thalamic Model Generates Multiple Distinct Oscillations with State-dependent Entrainment by Stimulation PLOS Computational Biology. 13(10)

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