We present a unified model of the thalamus that is capable of independently generating multiple distinct oscillations (delta, spindle, alpha and gamma oscillations) under different levels of acetylcholine (ACh) and norepinephrine (NE) modulation corresponding to different physiological conditions (deep sleep, light sleep, relaxed wakefulness and attention). The model also shows that entrainment of thalamic oscillations is state-dependent.
Model Type: Realistic Network
Region(s) or Organism(s): Thalamus
Cell Type(s): Thalamus geniculate nucleus/lateral principal GLU cell; Thalamus reticular nucleus GABA cell; Thalamus lateral geniculate nucleus interneuron
Currents: I Na,t; I K; I h; I L high threshold; I T low threshold; I_AHP; I CAN; I K,leak
Transmitters: Acetylcholine; Norephinephrine
Model Concept(s): Sleep; Activity Patterns; Gamma oscillations; Oscillations; Brain Rhythms
Simulation Environment: C or C++ program
Implementer(s): Li, Guoshi [guoshi_li at med.unc.edu]
References:
Li G, Henriquez CS, Fröhlich F. (2017). Unified Thalamic Model Generates Multiple Distinct Oscillations with State-dependent Entrainment by Stimulation PLOS Computational Biology. 13(10)