Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)

We construct an electric compartment model of the striatal medium spiny neuron with a realistic morphology and predict the calcium responses in the synaptic spines with variable timings of the glutamatergic and dopaminergic inputs and the postsynaptic action potentials. The model was validated by reproducing the responses to current inputs and could predict the electric and calcium responses to glutamatergic inputs and back-propagating action potential in the proximal and distal synaptic spines during up and down states.

Model Type: Neuron or other electrically excitable cell; Synapse

Cell Type(s): Neostriatum medium spiny direct pathway GABA cell

Currents: I Na,p; I Na,t; I L high threshold; I A; I K; I K,leak; I K,Ca; I CAN; I Sodium; I Calcium; I Potassium; I A, slow; I Krp; I R; I Q; I Na, leak; I Ca,p; Ca pump

Receptors: D1; AMPA; NMDA; Glutamate; Dopaminergic Receptor; IP3

Model Concept(s): Reinforcement Learning; STDP; Calcium dynamics; Reward-modulated STDP

Simulation Environment: NEURON

Implementer(s): Nakano, Takashi [nakano.takashi at]


Nakano T, Yoshimoto J, Doya K. (2013). A model-based prediction of the calcium responses in the striatal synaptic spines depending on the timing of cortical and dopaminergic inputs and post-synaptic spikes. Frontiers in computational neuroscience. 7 [PubMed]

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