Computer model was used to investigate the possible mechanisms of seizure initiation, progression and termination. The model was developed by complementing the Hodgkin-Huxley equations with activity-dependent changes in intra- and extracellular ion concentrations. The model incorporates a number of ionic mechanisms such as: active and passive membrane currents, inhibitory synaptic GABAA currents, Na/K pump, KCC2 cotransporter, glial K buffering, radial diffusion between extracellular space and bath, and longitudinal diffusion between dendritic and somatic compartments in pyramidal cells.
Model Type: Realistic Network; Extracellular
Region(s) or Organism(s): Entorhinal cortex
Cell Type(s): Entorhinal cortex pyramidal cell; Entorhinal cortex fast-spiking interneuron
Currents: Ca pump; I CAN; I Cl, leak; I K,Ca; I K,leak; I L high threshold; I M; I Na, leak; I Na,p; I Na,t; I_AHP; I_HCO3; KCC2; Na/K pump; Osmosis-driven water flux
Model Concept(s): Epilepsy; Dynamic extracellular concentrations
Simulation Environment: NEURON
Implementer(s): Suffczynski, Piotr [Piotr.Suffczynski at fuw.edu.pl]; Gentiletti, Damiano [gentiletti.damiano at gmail.com]
References:
Gentiletti D, de Curtis M, Gnatkovsky V, Suffczynski P. (2022). Focal seizures are organized by feedback between neural activity and ion concentration changes eLife. 11 [PubMed]