A focal seizure model with ion concentration changes (Gentiletti et al., 2022)

Computer model was used to investigate the possible mechanisms of seizure initiation, progression and termination. The model was developed by complementing the Hodgkin-Huxley equations with activity-dependent changes in intra- and extracellular ion concentrations. The model incorporates a number of ionic mechanisms such as: active and passive membrane currents, inhibitory synaptic GABAA currents, Na/K pump, KCC2 cotransporter, glial K buffering, radial diffusion between extracellular space and bath, and longitudinal diffusion between dendritic and somatic compartments in pyramidal cells.

Model Type: Realistic Network; Extracellular

Region(s) or Organism(s): Entorhinal cortex

Cell Type(s): Entorhinal cortex pyramidal cell; Entorhinal cortex fast-spiking interneuron

Currents: Ca pump; I CAN; I Cl, leak; I K,Ca; I K,leak; I L high threshold; I M; I Na, leak; I Na,p; I Na,t; I_AHP; I_HCO3; KCC2; Na/K pump; Osmosis-driven water flux

Receptors: AMPA; GabaA

Transmitters: Gaba; Glutamate

Model Concept(s): Epilepsy; Dynamic extracellular concentrations

Simulation Environment: NEURON

Implementer(s): Suffczynski, Piotr [Piotr.Suffczynski at fuw.edu.pl]; Gentiletti, Damiano [gentiletti.damiano at gmail.com]


Gentiletti D, de Curtis M, Gnatkovsky V, Suffczynski P. (2022). Focal seizures are organized by feedback between neural activity and ion concentration changes eLife. 11 [PubMed]

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