Layer V pyramidal cell functions and schizophrenia genetics (Mäki-Marttunen et al 2019)

Study on how GWAS-identified risk genes of shizophrenia affect excitability and integration of inputs in thick-tufted layer V pyramidal cells

Model Type: Neuron or other electrically excitable cell

Region(s) or Organism(s): Neocortex

Currents: I A; I M; I h; I K,Ca; I Calcium; I A, slow; I Na,t; I Na,p; I L high threshold; I T low threshold

Receptors: AMPA; NMDA; Gaba

Transmitters: Glutamate; Gaba

Model Concept(s): Schizophrenia; Dendritic Action Potentials; Action Potential Initiation; Synaptic Integration

Simulation Environment: NEURON; Python

Implementer(s): Maki-Marttunen, Tuomo [tuomomm at]


Mäki-Marttunen T et al. (2019). Computational modeling of genetic contributions to excitability and neural coding in layer V pyramidal cells: applications to schizophrenia pathology Front. Comput. Neurosci.. 13

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