Study on how GWAS-identified risk genes of shizophrenia affect excitability and integration of inputs in thick-tufted layer V pyramidal cells
Model Type: Neuron or other electrically excitable cell
Region(s) or Organism(s): Neocortex
Currents: I A; I M; I h; I K,Ca; I Calcium; I A, slow; I Na,t; I Na,p; I L high threshold; I T low threshold
Model Concept(s): Schizophrenia; Dendritic Action Potentials; Action Potential Initiation; Synaptic Integration
Simulation Environment: NEURON; Python
Implementer(s): Maki-Marttunen, Tuomo [tuomomm at uio.no]
References:
Mäki-Marttunen T et al. (2019). Computational modeling of genetic contributions to excitability and neural coding in layer V pyramidal cells: applications to schizophrenia pathology Front. Comput. Neurosci.. 13