In our model of a midbrain VTA dopamine neuron, we show that the decay kinetics of the A-type potassium current can control the timing of rebound action potentials.
Model Type: Neuron or other electrically excitable cell
Region(s) or Organism(s): Basal ganglia
Cell Type(s): Ventral tegmental area dopamine neuron
Currents: I A; I A, slow; I K,Ca; I Calcium; I Na, leak; I Na,t; I T low threshold; I L high threshold; I h; I K; I N; I R
Transmitters: Gaba
Model Concept(s): Ion Channel Kinetics; Action Potentials; Activity Patterns
Simulation Environment: GENESIS
Implementer(s): Evans, Rebekah [Rebekah.Evans at nih.gov]
References:
Tarfa RA, Evans RC, Khaliq ZM. (2017). Enhanced Sensitivity to Hyperpolarizing Inhibition in Mesoaccumbal Relative to Nigrostriatal Dopamine Neuron Subpopulations. The Journal of neuroscience : the official journal of the Society for Neuroscience. 37 [PubMed]