VTA dopamine neuron (Tarfa, Evans, and Khaliq 2017)

In our model of a midbrain VTA dopamine neuron, we show that the decay kinetics of the A-type potassium current can control the timing of rebound action potentials.

Model Type: Neuron or other electrically excitable cell

Region(s) or Organism(s): Basal ganglia

Cell Type(s): Ventral tegmental area dopamine neuron

Currents: I A; I A, slow; I K,Ca; I Calcium; I Na, leak; I Na,t; I T low threshold; I L high threshold; I h; I K; I N; I R

Receptors: GabaA; AMPA; NMDA

Transmitters: Gaba

Model Concept(s): Ion Channel Kinetics; Action Potentials; Activity Patterns

Simulation Environment: GENESIS

Implementer(s): Evans, Rebekah [Rebekah.Evans at nih.gov]


Tarfa RA, Evans RC, Khaliq ZM. (2017). Enhanced Sensitivity to Hyperpolarizing Inhibition in Mesoaccumbal Relative to Nigrostriatal Dopamine Neuron Subpopulations. The Journal of neuroscience : the official journal of the Society for Neuroscience. 37 [PubMed]

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