Sympathetic Preganglionic Neurone (Briant et al. 2014)

A model of a sympathetic preganglionic neurone of muscle vasoconstrictor-type.

Model Type: Neuron or other electrically excitable cell

Cell Type(s): Spinal cord lumbar motor neuron alpha ACh cell; Spinal cord sympathetic preganglionic neuron

Currents: I Na,t; I L high threshold; I N; I A; I K; I K,Ca; I_AHP

Model Concept(s): Action Potential Initiation; Activity Patterns; Bursting; Ion Channel Kinetics; Temporal Pattern Generation; Parameter Fitting; Action Potentials; Parameter sensitivity

Simulation Environment: NEURON; MATLAB


Briant LJ, Stalbovskiy AO, Nolan MF, Champneys AR, Pickering AE. (2014). Increased intrinsic excitability of muscle vasoconstrictor preganglionic neurons may contribute to the elevated sympathetic activity in hypertensive rats. Journal of neurophysiology. 112 [PubMed]

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