A model of a sympathetic preganglionic neurone of muscle vasoconstrictor-type.
Model Type: Neuron or other electrically excitable cell
Cell Type(s): Spinal cord lumbar motor neuron alpha ACh cell; Spinal cord sympathetic preganglionic neuron
Currents: I Na,t; I L high threshold; I N; I A; I K; I K,Ca; I_AHP
Model Concept(s): Action Potential Initiation; Activity Patterns; Bursting; Ion Channel Kinetics; Temporal Pattern Generation; Parameter Fitting; Action Potentials; Parameter sensitivity
Simulation Environment: NEURON; MATLAB
References:
Briant LJ, Stalbovskiy AO, Nolan MF, Champneys AR, Pickering AE. (2014). Increased intrinsic excitability of muscle vasoconstrictor preganglionic neurons may contribute to the elevated sympathetic activity in hypertensive rats. Journal of neurophysiology. 112 [PubMed]