The structure and the parameters of the model cells were chosen to reproduce the responses of type A and type B MVNns as described in electrophysiological recordings. The emergence of oscillatory firing under these two specific experimental conditions is consistent with electrophysiological recordings not used during construction of the model. We, therefore, suggest that these models have a high predictive value.
Model Type: Neuron or other electrically excitable cell
Cell Type(s): Vestibular neuron
Currents: I Na,p; I Na,t; I L high threshold; I T low threshold; I A; I K; I h
Receptors: NMDA
Model Concept(s): Oscillations; Action Potentials; Calcium dynamics
Simulation Environment: NEURON
Implementer(s): Morse, Tom [Tom.Morse at Yale.edu]
References:
Quadroni R, Knöpfel T. (1994). Compartmental models of type A and type B guinea pig medial vestibular neurons. Journal of neurophysiology. 72 [PubMed]