Activity dependent changes in motoneurones (Dai Y et al 2002, Gardiner et al 2002)

These two papers review various experimental papers and examine the effects of activity on motoneurons in a similar 5 compartment model with 10 active conductances. Included are slow (S) and fast (F) type and fast fatigue resistant (FR) and fast fatigable (FF) models corresponding to the types of motoneurons. See papers for more and details.

Model Type: Neuron or other electrically excitable cell

Cell Type(s): Spinal cord lumbar motor neuron alpha ACh cell

Currents: I Na,p; I Na,t; I L high threshold; I N; I T low threshold; I A; I K; I h; I Potassium

Model Concept(s): Activity Patterns; Ion Channel Kinetics; Simplified Models; Tutorial/Teaching

Simulation Environment: GENESIS

Implementer(s): Dai, Yue [ydai at]


Dai Y, Jones KE, Fedirchuk B, McCrea DA, Jordan LM. (2002). A modelling study of locomotion-induced hyperpolarization of voltage threshold in cat lumbar motoneurones. The Journal of physiology. 544 [PubMed]

Gardiner P, Dai Y, Heckman CJ. (2006). Effects of exercise training on alpha-motoneurons. Journal of applied physiology (Bethesda, Md. : 1985). 101 [PubMed]

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