" ... Here we adapted an existing computational model of the dentate gyrus (J Neurophysiol 93: 437-453, 2005) by replacing the reduced granule cell models with morphologically detailed models coming from (3D) reconstructions of mature cells. ... Different fractions of the mature granule cell models were replaced by morphologically reconstructed models of newborn dentate granule cells from animals with PILO-induced Status Epilepticus, which have apical dendritic alterations and spine loss, and control animals, which do not have these alterations. This complex arrangement of cells and processes allowed us to study the combined effect of mossy fiber sprouting, altered apical dendritic tree and dendritic spine loss in newborn granule cells on the excitability of the dentate gyrus model. Our simulations suggest that alterations in the apical dendritic tree and dendritic spine loss in newborn granule cells have opposing effects on the excitability of the dentate gyrus after Status Epilepticus. Apical dendritic alterations potentiate the increase of excitability provoked by mossy fiber sprouting while spine loss curtails this increase. "
Model Type: Realistic Network
Region(s) or Organism(s): Dentate gyrus
Cell Type(s): Dentate gyrus granule GLU cell; Dentate gyrus mossy cell; Dentate gyrus basket cell; Dentate gyrus hilar cell
Currents: I L high threshold; I T low threshold; I K; I h; I K,Ca; I Calcium; I Potassium
Model Concept(s): Activity Patterns; Spatio-temporal Activity Patterns; Epilepsy; Neurogenesis
Simulation Environment: NEURON
Implementer(s): Tejada, Julian [julian.tejada at gmail.com]
References:
Tejada J, Garcia-Cairasco N, Roque AC. (2014). Combined role of seizure-induced dendritic morphology alterations and spine loss in newborn granule cells with mossy fiber sprouting on the hyperexcitability of a computer model of the dentate gyrus. PLoS computational biology. 10 [PubMed]
Tejada J, Arisi GM, García-Cairasco N, Roque AC. (2012). Morphological alterations in newly born dentate gyrus granule cells that emerge after status epilepticus contribute to make them less excitable. PloS one. 7 [PubMed]