A spiny dendrite model supports the hypothesis that only inhibitory inputs on spine heads, not shafts, compartmentalizes inhibition of calcium signals to spine heads as seen in paired inhibition with back-propagating action potential experiments on prefrontal cortex layer 2/3 pyramidal neurons in mouse (Chiu et al. 2013).
Region(s) or Organism(s): Neocortex
Cell Type(s): Neocortex L2/3 pyramidal GLU cell
Currents: I Na,t; I L high threshold; I K
Receptors: GabaA
Model Concept(s): Dendritic Action Potentials; Influence of Dendritic Geometry
Simulation Environment: NEURON
Implementer(s): Carnevale, Ted [Ted.Carnevale at Yale.edu]; Morse, Tom [Tom.Morse at Yale.edu]
References:
Chiu CQ et al. (2013). Compartmentalization of GABAergic inhibition by dendritic spines. Science (New York, N.Y.). 340 [PubMed]