A spiny dendrite model supports the hypothesis that only inhibitory inputs on spine heads, not shafts, compartmentalizes inhibition of calcium signals to spine heads as seen in paired inhibition with back-propagating action potential experiments on prefrontal cortex layer 2/3 pyramidal neurons in mouse (Chiu et al. 2013).
Region(s) or Organism(s): Neocortex
Cell Type(s): Neocortex L2/3 pyramidal GLU cell
Simulation Environment: NEURON