Kinetic synaptic models applicable to building networks (Destexhe et al 1998)

Simplified AMPA, NMDA, GABAA, and GABAB receptor models useful for building networks are described in a book chapter. One reference paper synthesizes a comprehensive general description of synaptic transmission with Markov kinetic models which is applicable to modeling ion channels, synaptic release, and all receptors. Also a simple introduction to this method is given in a seperate paper Destexhe et al Neural Comput 6:14-18 , 1994). More information and papers at http://cns.iaf.cnrs-gif.fr/Main.html and through email: Destexhe@iaf.cnrs-gif.fr

Model Type: Synapse

Receptors: GabaA; GabaB; AMPA; NMDA; Glutamate; Gaba

Transmitters: Gaba; Glutamate

Model Concept(s): Ion Channel Kinetics; Simplified Models; Markov-type model

Simulation Environment: NEURON

Implementer(s): Destexhe, Alain [Destexhe at iaf.cnrs-gif.fr]; Mainen, Zach [Mainen at cshl.edu]

References:

Destexhe A, Mainen ZF, Sejnowski TJ. (1994). Synthesis of models for excitable membranes, synaptic transmission and neuromodulation using a common kinetic formalism. Journal of computational neuroscience. 1 [PubMed]

Sejnowski TJ, Destexhe A, Mainen ZF. (1998). Kinetic models of synaptic transmission Methods In Neuronal Modeling.

Sejnowski TJ, Destexhe A, Mainen Z. (1994). An efficient method for computing synaptic conductances based on a kinetic model of receptor binding Neural Comput. 6