Bursting and resonance in cerebellar granule cells (D'Angelo et al. 2001)

In this study we report theta-frequency (3-12 Hz) bursting and resonance in rat cerebellar granule cells and show that these neurons express a previously unidentified slow repolarizing K1 current (IK-slow ). Our experimental and modeling results indicate that IK-slow was necessary for both bursting and resonance. See paper for more.

Model Type: Neuron or other electrically excitable cell

Cell Type(s): Cerebellum interneuron granule GLU cell

Currents: I A; I K; I h; I Calcium; I A, slow

Model Concept(s): Bursting; Ion Channel Kinetics; Oscillations

Simulation Environment: NEURON

Implementer(s): D'Angelo, Egidio [dangelo at unipv.it]

References:

D'Angelo E et al. (2001). Theta-frequency bursting and resonance in cerebellar granule cells: experimental evidence and modeling of a slow k+-dependent mechanism. The Journal of neuroscience : the official journal of the Society for Neuroscience. 21 [PubMed]