Pyramidal neurons: IKHT offsets activation of IKLT to increase gain (Fernandez et al 2005)

This matlab model was supplied by Dr Fernandez. It provides the model specification for the below paper. The influence of a high threshold K current on low threshold K and Na currents (especially frequency-current relationships) are studied in the paper with both experiments and modeling. Please see the reference for more and details.

Cell Type(s): ELL pyramidal cell

Currents: I Na,t; I K; I Potassium; I_KHT; I_KLT

Model Concept(s): Activity Patterns; Ion Channel Kinetics

Simulation Environment: MATLAB

Implementer(s): Fernandez FR [ffernand at]; Mehaffey WH


Fernandez FR, Mehaffey WH, Molineux ML, Turner RW. (2005). High-threshold K+ current increases gain by offsetting a frequency-dependent increase in low-threshold K+ current. The Journal of neuroscience : the official journal of the Society for Neuroscience. 25 [PubMed]

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