NMDA receptor saturation (Chen et al 2001)

Experiments and modeling reported in the paper Chen N, Ren J, Raymond LA, and Murphy T (2001) support the hypothesis that glutamate has a relatively lower potency at NMDARs than previously thought from agonist application under equilibrium conditions. Further information and reprint requests are available from Dr T.H. Murphy thmurphy at interchange.ubc.ca

Model Type: Synapse

Receptors: NMDA


Transmitters: Glutamate

Model Concept(s): Ion Channel Kinetics

Simulation Environment: NEURON

Implementer(s): Murphy, Tim H [THMurphy at interchange.ubc.ca]


Chen N, Ren J, Raymond LA, Murphy TH. (2001). Changes in agonist concentration dependence that are a function of duration of exposure suggest N-methyl-D-aspartate receptor nonsaturation during synaptic stimulation. Molecular pharmacology. 59 [PubMed]

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