Experiments and modeling reported in the paper Chen N, Ren J, Raymond LA, and Murphy T (2001) support the hypothesis that glutamate has a relatively lower potency at NMDARs than previously thought from agonist application under equilibrium conditions. Further information and reprint requests are available from Dr T.H. Murphy thmurphy at interchange.ubc.ca
Model Type: Synapse
Receptors: NMDA
Genes: NR2A GRIN2A; NR2B GRIN2B
Transmitters: Glutamate
Model Concept(s): Ion Channel Kinetics
Simulation Environment: NEURON
Implementer(s): Murphy, Tim H [THMurphy at interchange.ubc.ca]
References:
Chen N, Ren J, Raymond LA, Murphy TH. (2001). Changes in agonist concentration dependence that are a function of duration of exposure suggest N-methyl-D-aspartate receptor nonsaturation during synaptic stimulation. Molecular pharmacology. 59 [PubMed]