Maximal firing rate in midbrain dopamine neurons (Knowlton et al., 2021)

Model Type: Neuron or other electrically excitable cell

Cell Type(s): Substantia nigra pars compacta DA cell; Ventral tegmental area dopamine neuron

Currents: I Na, slow inactivation

Receptors: NMDA

Model Concept(s): Depolarization block; Ion Channel Kinetics; Markov-type model; Bursting

Simulation Environment: NEURON; Python

Implementer(s): Knowlton, Christopher [cknow1 at lsuhsc.edu]

References:

Knowlton CJ, Ziouziou TI, Hammer N, Roeper J, Canavier CC. (2021). Inactivation mode of sodium channels defines the different maximal firing rates of conventional versus atypical midbrain dopamine neurons PLoS computational biology. 17 [PubMed]