"Burst firing in medial substantia nigra dopamine (mSN DA) neurons has been selectively linked to novelty-induced exploration behavior in mice. Burst firing in mSN DA neurons, in contrast to lateral SN DA neurons, requires functional ATP-sensitive potassium channels (K-ATP) both in vitro and in vivo. However, the precise role of K-ATP channels in promoting burst firing is un-known. We show experimentally that L-type calcium channel activity in mSN DA neurons en-hances open probability of K-ATP channels. We then generated a mathematical model to study the role of Ca2+ dynamics driving K-ATP channel function in mSN DA neurons during bursting. ..."
Model Type: Neuron or other electrically excitable cell
Region(s) or Organism(s): Basal ganglia
Cell Type(s): Substantia nigra pars compacta DA cell
Simulation Environment: C or C++ program
Knowlton C, Kutterer S, Roeper J, Canavier CC. (2018). Calcium dynamics control K-ATP channel-mediated bursting in substantia nigra dopamine neurons: a combined experimental and modeling study. Journal of neurophysiology. 119 [PubMed]