Enhancing the HH eqs: simulations based on the first publication in Biophys J (Moore 2015)

"The experiments in the Cole and Moore article in the first issue of the Biophysical Journal provided the first independent experimental confirmation of the Hodgkin-Huxley (HH) equations. A log-log plot of the K current versus time showed that raising the HH variable n to the sixth power provided the best fit to the data. Subsequent simulations using n6 and setting the resting potential at the in vivo value simplifies the HH equations by eliminating the leakage term. ..."

Model Type: Neuron or other electrically excitable cell

Cell Type(s): Squid axon

Currents: I Na,t; I K

Model Concept(s): Ion Channel Kinetics; Action Potentials

Simulation Environment: NEURON

Implementer(s): Hines, Michael [Michael.Hines at Yale.edu]; Moore, John W [moore at neuro.duke.edu]

References:

Moore JW. (2015). Enhancing the Hodgkin-Huxley Equations: Simulations Based on the First Publication in the Biophysical Journal. Biophysical journal. 109 [PubMed]