Model of calcium oscillations in olfactory cilia (Reidl et al. 2006)

Simulation of experiments on olfactory receptor neurons (ORNs). Focussing on the negative feedback that calcium (through calmodulin) has on its own influx through CNG channels, this model is able to reproduce both calcium oscillations as well as adaptation behaviour as seen in experiments done with ORNs.

Model Type: Dendrite

Cell Type(s): Olfactory receptor GLU cell

Currents: I CNG

Model Concept(s): Activity Patterns; Ion Channel Kinetics; Temporal Pattern Generation; Oscillations; Simplified Models; Signaling pathways; Calcium dynamics; Olfaction

Simulation Environment: MATLAB


Reidl J et al. (2006). Model of calcium oscillations due to negative feedback in olfactory cilia. Biophysical journal. 90 [PubMed]

Borowski P. (2006). Stochastic dynamics in olfactory signal transduction and development, Dissertation

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