Simulation of experiments on olfactory receptor neurons (ORNs). Focussing on the negative feedback that calcium (through calmodulin) has on its own influx through CNG channels, this model is able to reproduce both calcium oscillations as well as adaptation behaviour as seen in experiments done with ORNs.
Model Type: Dendrite
Cell Type(s): Olfactory receptor GLU cell
Currents: I CNG
Model Concept(s): Activity Patterns; Ion Channel Kinetics; Temporal Pattern Generation; Oscillations; Simplified Models; Signaling pathways; Calcium dynamics; Olfaction
Simulation Environment: MATLAB
References:
Reidl J et al. (2006). Model of calcium oscillations due to negative feedback in olfactory cilia. Biophysical journal. 90 [PubMed]
Borowski P. (2006). Stochastic dynamics in olfactory signal transduction and development, Dissertation http://nbn-resolving.de/urn:nbn:de:swb:14-1159519135136-2269.