These are two or triple-exponential models of the voltage-dependent NMDA receptors. Conductance of these receptors increase voltage-dependently with a "Hodgkin and Huxley-type" gating style that is also depending on glutamate-binding. Time course of the gating of these receptors in response to glutamate are also changing voltage-dependently. Temperature sensitivity and desensitization of these receptor are also taken into account. Three previous kinetic models that are able to simulate the voltage-dependence of the NMDARs are also imported to the NMODL. These models are not temperature sensitive. These models are compatible with the "event delivery system" of NEURON. Parameters that are reported in our paper are applicable to CA1 pyramidal cell dendrites.
Model Type: Synapse
Region(s) or Organism(s): Neocortex; Hippocampus
Cell Type(s): Hippocampus CA1 pyramidal GLU cell
Genes: NR2B GRIN2B
Transmitters: Glutamate
Model Concept(s): Ion Channel Kinetics; Simplified Models; Long-term Synaptic Plasticity; Methods
Simulation Environment: NEURON
Implementer(s): Moradi, Keivan [k.moradi at gmail.com]
References:
Moradi K et al. (2013). A fast model of voltage-dependent NMDA receptors. Journal of computational neuroscience. 34 [PubMed]