A cardiac cell simulator (Puglisi and Bers 2001), applied to the QT interval (Busjahn et al 2004)

"LabHEART is an easy to use program that simulates the cardiac action potential, calcium transient and ionic currents. Key parameters such as ionic concentration, stimulus waveform and channel conductance can easily be changed by a click on an icon or dragging a slider. It is a powerfull tool for teaching and researching cardiac electrophysiology."

Model Type: Neuron or other electrically excitable cell

Cell Type(s): Heart cell; Cardiac ventricular cell

Model Concept(s): Ion Channel Kinetics; Temporal Pattern Generation; Tutorial/Teaching; Action Potentials; Heart disease

Simulation Environment: MATLAB (web link to model)

Implementer(s): Bers, Donald M; Puglisi, Jose ; Salah, Wajeeh


Puglisi JL, Bers DM. (2001). LabHEART: an interactive computer model of rabbit ventricular myocyte ion channels and Ca transport. American journal of physiology. Cell physiology. 281 [PubMed]

Busjahn A et al. (2004). Association of the serum and glucocorticoid regulated kinase (sgk1) gene with QT interval. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 14 [PubMed]

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