Periodicity in Na channel properties alters model neuron excitability (Majumdar and Sikdar 2007)

"... We have shown earlier that the duration and amplitude of a prolonged depolarization alter all the steady state and kinetic parameters of rNav1.2a voltage gated Na channel in a pseudo-oscillatory fashion. In the present study, we show that the Hodgkin–Huxley voltage and time dependent rate constants of activation (am and bm) and fast inactivation (ah and bh), obtained from the analyses of Na currents and steady state activation and inactivation plots, following application of prepulses in both slow (1–100 s) and fast (100–1000 ms) ranges, vary with the duration of a prepulse in a pseudo-oscillatory manner. ..."

Model Type: Neuron or other electrically excitable cell

Currents: I Na,t; I K

Model Concept(s): Ion Channel Kinetics; Epilepsy

Simulation Environment: GENESIS


Sikdar SK, Majumdar S. (). Periodicity in Na+ channel properties alters excitability of a model neuron Biochem Biophys Res Commun.. (in press)

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