A model of canine I:(to1) (the Ca(2+)-independent transient outward current) is formulated as the combination of Kv4.3 and Kv1.4 currents and is incorporated into an existing canine ventricular myocyte model. Simulations demonstrate strong coupling between L-type Ca(2+) current and I:(Kv4.3) and predict a bimodal relationship between I:(Kv4.3) density and APD whereby perturbations in I:(Kv4.3) density may produce either prolongation or shortening of APD, depending on baseline I:(to1) current level. The model files were submitted by: Dr. Sheng-Nan Wu, Dr. Ruey J. Sung, Ya-Jean Wang and Jiun-Shian Wu e-mail: snwu@mail.ncku.edu.tw
Model Type: Channel/Receptor
Currents: I A
Genes: Kv4.3 KCND3; Kv1.4 KCNA4
Model Concept(s): Ion Channel Kinetics; Heart disease
Simulation Environment: XPPAUT
Implementer(s): Wu, Sheng-Nan [snwu at mail.ncku.edu.tw]; Wu, Jiun-Shian [coolneon at gmail.com]; Sung, Ruey J ; Wang, Ya-Jean
References:
Greenstein JL, Wu R, Po S, Tomaselli GF, Winslow RL. (2000). Role of the calcium-independent transient outward current I(to1) in shaping action potential morphology and duration. Circulation research. 87 [PubMed]