An WF et al. (2000). Modulation of A-type potassium channels by a family of calcium sensors. Nature. 403 [PubMed]
Barry DM, Xu H, Schuessler RB, Nerbonne JM. (1998). Functional knockout of the transient outward current, long-QT syndrome, and cardiac remodeling in mice expressing a dominant-negative Kv4 alpha subunit. Circulation research. 83 [PubMed]
Beuckelmann DJ, Näbauer M, Erdmann E. (1993). Alterations of K+ currents in isolated human ventricular myocytes from patients with terminal heart failure. Circulation research. 73 [PubMed]
Brahmajothi MV et al. (1999). Distinct transient outward potassium current (Ito) phenotypes and distribution of fast-inactivating potassium channel alpha subunits in ferret left ventricular myocytes. The Journal of general physiology. 113 [PubMed]
Dilks D, Ling HP, Cockett M, Sokol P, Numann R. (1999). Cloning and expression of the human kv4.3 potassium channel. Journal of neurophysiology. 81 [PubMed]
Dixon JE et al. (1996). Role of the Kv4.3 K+ channel in ventricular muscle. A molecular correlate for the transient outward current. Circulation research. 79 [PubMed]
Dumaine R et al. (1999). Ionic mechanisms responsible for the electrocardiographic phenotype of the Brugada syndrome are temperature dependent. Circulation research. 85 [PubMed]
Faivre JF et al. (1999). Characterisation of Kv4.3 in HEK293 cells: comparison with the rat ventricular transient outward potassium current. Cardiovascular research. 41 [PubMed]
Flesch M et al. (1996). Evidence for functional relevance of an enhanced expression of the Na(+)-Ca2+ exchanger in failing human myocardium. Circulation. 94 [PubMed]
Guo W, Li H, London B, Nerbonne JM. (2000). Functional consequences of elimination of i(to,f) and i(to,s): early afterdepolarizations, atrioventricular block, and ventricular arrhythmias in mice lacking Kv1.4 and expressing a dominant-negative Kv4 alpha subunit. Circulation research. 87 [PubMed]
Hamill OP, Marty A, Neher E, Sakmann B, Sigworth FJ. (1981). Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Archiv : European journal of physiology. 391 [PubMed]
Hoppe UC, Johns DC, Marbán E, O'Rourke B. (1999). Manipulation of cellular excitability by cell fusion: effects of rapid introduction of transient outward K+ current on the guinea pig action potential. Circulation research. 84 [PubMed]
Jafri MS, Rice JJ, Winslow RL. (1998). Cardiac Ca2+ dynamics: the roles of ryanodine receptor adaptation and sarcoplasmic reticulum load. Biophysical journal. 74 [PubMed]
Kong W et al. (1998). Isolation and characterization of the human gene encoding Ito: further diversity by alternative mRNA splicing. The American journal of physiology. 275 [PubMed]
Kääb S et al. (1998). Molecular basis of transient outward potassium current downregulation in human heart failure: a decrease in Kv4.3 mRNA correlates with a reduction in current density. Circulation. 98 [PubMed]
Kääb S et al. (1996). Ionic mechanism of action potential prolongation in ventricular myocytes from dogs with pacing-induced heart failure. Circulation research. 78 [PubMed]
Li GR, Feng J, Yue L, Carrier M. (1998). Transmural heterogeneity of action potentials and Ito1 in myocytes isolated from the human right ventricle. The American journal of physiology. 275 [PubMed]
Litovsky SH, Antzelevitch C. (1989). Rate dependence of action potential duration and refractoriness in canine ventricular endocardium differs from that of epicardium: role of the transient outward current. Journal of the American College of Cardiology. 14 [PubMed]
Liu DW, Gintant GA, Antzelevitch C. (1993). Ionic bases for electrophysiological distinctions among epicardial, midmyocardial, and endocardial myocytes from the free wall of the canine left ventricle. Circulation research. 72 [PubMed]
Lukas A, Antzelevitch C. (1993). Differences in the electrophysiological response of canine ventricular epicardium and endocardium to ischemia. Role of the transient outward current. Circulation. 88 [PubMed]
Luo CH, Rudy Y. (1994). A dynamic model of the cardiac ventricular action potential. I. Simulations of ionic currents and concentration changes. Circulation research. 74 [PubMed]
McKinnon D et al. (2000). Effects of the renin-angiotensin system on the current I(to) in epicardial and endocardial ventricular myocytes from the canine heart. Circ Res. 86
Meyer M et al. (1995). Alterations of sarcoplasmic reticulum proteins in failing human dilated cardiomyopathy. Circulation. 92
Näbauer M, Beuckelmann DJ, Erdmann E. (1993). Characteristics of transient outward current in human ventricular myocytes from patients with terminal heart failure. Circulation research. 73 [PubMed]
Näbauer M, Beuckelmann DJ, Uberfuhr P, Steinbeck G. (1996). Regional differences in current density and rate-dependent properties of the transient outward current in subepicardial and subendocardial myocytes of human left ventricle. Circulation. 93 [PubMed]
Po S, Roberds S, Snyders DJ, Tamkun MM, Bennett PB. (1993). Heteromultimeric assembly of human potassium channels. Molecular basis of a transient outward current? Circulation research. 72 [PubMed]
Po S, Snyders DJ, Baker R, Tamkun MM, Bennett PB. (1992). Functional expression of an inactivating potassium channel cloned from human heart. Circulation research. 71 [PubMed]
Stengl M, Carmeliet E, Mubagwa K, Flameng W. (1998). Modulation of transient outward current by extracellular protons and Cd2+ in rat and human ventricular myocytes. The Journal of physiology. 511 ( Pt 3) [PubMed]
Studer R et al. (1994). Gene expression of the cardiac Na(+)-Ca2+ exchanger in end-stage human heart failure. Circulation research. 75 [PubMed]
Wettwer E, Amos GJ, Posival H, Ravens U. (1994). Transient outward current in human ventricular myocytes of subepicardial and subendocardial origin. Circulation research. 75 [PubMed]
Wickenden AD, Jegla TJ, Kaprielian R, Backx PH. (1999). Regional contributions of Kv1.4, Kv4.2, and Kv4.3 to transient outward K+ current in rat ventricle. The American journal of physiology. 276 [PubMed]
Winslow RL, Rice J, Jafri S, Marbán E, O'Rourke B. (1999). Mechanisms of altered excitation-contraction coupling in canine tachycardia-induced heart failure, II: model studies. Circulation research. 84 [PubMed]
Zagotta WN, Aldrich RW. (1990). Voltage-dependent gating of Shaker A-type potassium channels in Drosophila muscle. The Journal of general physiology. 95 [PubMed]
Zygmunt AC, Robitelle DC, Eddlestone GT. (1997). Ito1 dictates behavior of ICl(Ca) during early repolarization of canine ventricle. The American journal of physiology. 273 [PubMed]
Clancy CE, Rudy Y. (2002). Na(+) channel mutation that causes both Brugada and long-QT syndrome phenotypes: a simulation study of mechanism. Circulation. 105 [PubMed]
Flaim SN, Giles WR, McCulloch AD. (2006). Contributions of sustained INa and IKv43 to transmural heterogeneity of early repolarization and arrhythmogenesis in canine left ventricular myocytes. American journal of physiology. Heart and circulatory physiology. 291 [PubMed]
Greenstein JL, Hinch R, Winslow RL. (2006). Mechanisms of excitation-contraction coupling in an integrative model of the cardiac ventricular myocyte. Biophysical journal. 90 [PubMed]
Greenstein JL, Tanskanen AJ, Winslow RL. (2004). Modeling the actions of beta-adrenergic signaling on excitation--contraction coupling processes. Annals of the New York Academy of Sciences. 1015 [PubMed]
Greenstein JL, Winslow RL. (2002). An integrative model of the cardiac ventricular myocyte incorporating local control of Ca2+ release. Biophysical journal. 83 [PubMed]
Hund TJ, Rudy Y. (2004). Rate dependence and regulation of action potential and calcium transient in a canine cardiac ventricular cell model. Circulation. 110 [PubMed]
Iyer V, Mazhari R, Winslow RL. (2004). A computational model of the human left-ventricular epicardial myocyte. Biophysical journal. 87 [PubMed]
Liu YC, Wang YJ, Wu SN. (2008). The mechanisms of propofol-induced block on ion currents in differentiated H9c2 cardiac cells. European journal of pharmacology. 590 [PubMed]
Mazhari R, Greenstein JL, Winslow RL, Marbán E, Nuss HB. (2001). Molecular interactions between two long-QT syndrome gene products, HERG and KCNE2, rationalized by in vitro and in silico analysis. Circulation research. 89 [PubMed]
Patel SP, Campbell DL. (2005). Transient outward potassium current, 'Ito', phenotypes in the mammalian left ventricle: underlying molecular, cellular and biophysical mechanisms. The Journal of physiology. 569 [PubMed]
Tanskanen AJ, Greenstein JL, O'Rourke B, Winslow RL. (2005). The role of stochastic and modal gating of cardiac L-type Ca2+ channels on early after-depolarizations. Biophysical journal. 88 [PubMed]
Winslow RL, Cortassa S, Greenstein JL. (2005). Using models of the myocyte for functional interpretation of cardiac proteomic data. The Journal of physiology. 563 [PubMed]