Simulating ion channel noise in an auditory brainstem neuron model (Schmerl & McDonnell 2013)

" ... Here we demonstrate that biophysical models of channel noise can give rise to two kinds of recently discovered stochastic facilitation effects in a Hodgkin-Huxley-like model of auditory brainstem neurons. The first, known as slope-based stochastic resonance (SBSR), enables phasic neurons to emit action potentials that can encode the slope of inputs that vary slowly relative to key time constants in the model. The second, known as inverse stochastic resonance (ISR), occurs in tonically firing neurons when small levels of noise inhibit tonic firing and replace it with burstlike dynamics. ..." Preprint available at

Model Type: Neuron or other electrically excitable cell; Channel/Receptor

Region(s) or Organism(s): Auditory brainstem

Cell Type(s): Cochlear nucleus bushy GLU cell; CN stellate cell; Ventral cochlear nucleus T stellate (chopper) neuron; Hodgkin-Huxley neuron

Currents: I h; I Sodium; I Potassium

Genes: Kv1.1 KCNA1; Kv3.1 KCNC1

Model Concept(s): Bursting; Ion Channel Kinetics; Action Potentials; Methods; Noise Sensitivity; Bifurcation; Audition

Simulation Environment: MATLAB


Schmerl BA, McDonnell MD. (2013). Channel noise induced stochastic facilitation in an auditory brainstem neuron model Physical review. E, Statistical, nonlinear, and soft matter physics. 88 [PubMed]

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