" ... Here we demonstrate that biophysical models of channel noise can give rise to two kinds of recently discovered stochastic facilitation effects in a Hodgkin-Huxley-like model of auditory brainstem neurons. The first, known as slope-based stochastic resonance (SBSR), enables phasic neurons to emit action potentials that can encode the slope of inputs that vary slowly relative to key time constants in the model. The second, known as inverse stochastic resonance (ISR), occurs in tonically firing neurons when small levels of noise inhibit tonic firing and replace it with burstlike dynamics. ..." Preprint available at http://arxiv.org/abs/1311.2643
Model Type: Neuron or other electrically excitable cell; Channel/Receptor
Region(s) or Organism(s): Auditory brainstem
Cell Type(s): Cochlear nucleus bushy GLU cell; CN stellate cell; Ventral cochlear nucleus T stellate (chopper) neuron; Hodgkin-Huxley neuron
Currents: I h; I Sodium; I Potassium
Genes: Kv1.1 KCNA1; Kv3.1 KCNC1
Model Concept(s): Bursting; Ion Channel Kinetics; Action Potentials; Methods; Noise Sensitivity; Bifurcation; Audition
Simulation Environment: MATLAB
References:
Schmerl BA, McDonnell MD. (2013). Channel noise induced stochastic facilitation in an auditory brainstem neuron model Physical review. E, Statistical, nonlinear, and soft matter physics. 88 [PubMed]