"Small dorsal root ganglion (DRG) neurons, which include nociceptors, express multiple voltage-gated sodium currents. In addition to a classical fast inactivating tetrodotoxin-sensitive (TTX-S) sodium current, many of these cells express a TTX-resistant (TTX-R) sodium current that activates near -70 mV and is persistent at negative potentials. To investigate the possible contributions of this TTX-R persistent (TTX-RP) current to neuronal excitability, we carried out computer simulations using the Neuron program with TTX-S and -RP currents, fit by the Hodgkin-Huxley model, that closely matched the currents recorded from small DRG neurons. ..." See paper for more and details.
Model Type: Neuron or other electrically excitable cell
Cell Type(s): Dorsal Root Ganglion (DRG) cell
Genes: Nav1.1 SCN1A; Nav1.6 SCN8A; Nav1.7 SCN9A; Nav1.8 SCN10A; Nav1.9 SCN11A SCN12A
Model Concept(s): Ion Channel Kinetics; Nociception
Simulation Environment: NEURON
Implementer(s): Morse, Tom [Tom.Morse at Yale.edu]
References:
Herzog RI, Cummins TR, Waxman SG. (2001). Persistent TTX-resistant Na+ current affects resting potential and response to depolarization in simulated spinal sensory neurons. Journal of neurophysiology. 86 [PubMed]