Na channel mutations in the dentate gyrus (Thomas et al. 2009)


These are source files to generate the data in Figure 6 from "Mossy fiber sprouting interacts with sodium channel mutations to increase dentate gyrus excitability" Thomas EA, Reid CA, Petrou S, Epilepsia (2009)

Model Type: Realistic Network

Cell Type(s): Dentate gyrus granule GLU cell; Dentate gyrus mossy cell; Dentate gyrus basket cell; Dentate gyrus hilar cell

Currents: I Na,t; I A; I K; I K,leak; I K,Ca; I Calcium

Receptors: GabaA; AMPA

Transmitters: Gaba; Glutamate

Model Concept(s): Ion Channel Kinetics; Epilepsy

Simulation Environment: parplex

Implementer(s): Thomas, Evan [evan at evan-thomas.net]

References:

Thomas EA, Reid CA, Petrou S. (2010). Mossy fiber sprouting interacts with sodium channel mutations to increase dentate gyrus excitability. Epilepsia. 51 [PubMed]


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