Zebrafish Mauthner-cell model (Watanabe et al 2017)

The NEURON model files encode the channel generator and firing simulator for simulating development and differentiation of the Mauthner cell (M-cell) excitability in zebrafish. The channel generator enables us to generate arbitrary Na+ and K+ channels by changing parameters of a Hodgkin-Huxley model under emulation of two-electrode voltage-clamp recordings in Xenopus oocyte system. The firing simulator simulates current-clamp recordings to generate firing patterns of the model M-cell, which are implemented with arbitrary-generated basic Na+ and K+ conductances and low-threshold K+ channels Kv7.4/KCNQ4 and sole Kv1.1 or Kv1.1 coexpressed with Kvbeta2.

Region(s) or Organism(s): Brainstem

Cell Type(s): Mauthner cell

Currents: I Potassium; I A; I_KLT; I_KHT; I M; I Sodium

Genes: Kv1.1 KCNA1; Kv7.4 KCNQ4; Kvb2 KCNAB2

Model Concept(s): Spike Frequency Adaptation; Bursting; Ion Channel Kinetics

Simulation Environment: NEURON

Implementer(s): Watanabe, Takaki [wtakaki at m.u-tokyo.ac.jp]


Watanabe T, Shimazaki T, Oda Y. (2017). Coordinated Expression of Two Types of Low-Threshold K+ Channels Establishes Unique Single Spiking of Mauthner Cells among Segmentally Homologous Neurons in the Zebrafish Hindbrain. eNeuro. 4 [PubMed]

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