Novel Na current with slow de-inactivation (Tsutsui, Oka 2002)

The authors found a novel Na current in teleost thalamic nuclei was well described by the m^3 h Hodgkin-Huxley model. The kinetic parameters derived from their experiments (see the reference for details) revealed that the h gate had a large time constant (~100ms at -80 to -50mV). This explains the thalamic neurons long refractory period and the gradual recovery of AP amplitude as the inter spike interval grows.

Model Type: Channel/Receptor

Cell Type(s): Teleost thalamic neuron

Currents: I Na,t; I K; I Sodium; I Potassium

Model Concept(s): Activity Patterns; Ion Channel Kinetics; Axonal Action Potentials; Action Potentials

Simulation Environment: NEURON

Implementer(s): Tsutsui, H


Tsutsui H, Oka Y. (2002). Slow removal of Na(+) channel inactivation underlies the temporal filtering property in the teleost thalamic neurons. The Journal of physiology. 539 [PubMed]

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