The authors found a novel Na current in teleost thalamic nuclei was well described by the m^3 h Hodgkin-Huxley model. The kinetic parameters derived from their experiments (see the reference for details) revealed that the h gate had a large time constant (~100ms at -80 to -50mV). This explains the thalamic neurons long refractory period and the gradual recovery of AP amplitude as the inter spike interval grows.
Model Type: Channel/Receptor
Cell Type(s): Teleost thalamic neuron
Currents: I Na,t; I K; I Sodium; I Potassium
Model Concept(s): Activity Patterns; Ion Channel Kinetics; Axonal Action Potentials; Action Potentials
Simulation Environment: NEURON
Implementer(s): Tsutsui, H
References:
Tsutsui H, Oka Y. (2002). Slow removal of Na(+) channel inactivation underlies the temporal filtering property in the teleost thalamic neurons. The Journal of physiology. 539 [PubMed]