Efficient Method for Computing Synaptic Conductance (Destexhe et al 1994)

A simple model of transmitter release is used to solve first order kinetic equations of neurotransmiter/receptor binding. This method is applied to a glutamate and gabaa receptor. See reference for more details. The method is extended to more complex kinetic schemes in a seperate paper (Destexhe et al J Comp Neuro 1:195-231, 1994). Application to AMPA, NMDA, GABAA, and GABAB receptors is given in a book chapter (Destexhe et al In: The Neurobiology of Computation, Edited by Bower, J., Kluwer Academic Press, Norwell MA, 1995, pp. 9-14.) More information and papers at http://cns.iaf.cnrs-gif.fr/Main.html and through email: Destexhe@iaf.cnrs-gif.fr

Model Type: Synapse

Receptors: GabaA; Glutamate; Gaba

Transmitters: Gaba; Glutamate

Model Concept(s): Ion Channel Kinetics

Simulation Environment: NEURON

Implementer(s): Destexhe, Alain [Destexhe at iaf.cnrs-gif.fr]; Mainen, Zach [Mainen at cshl.edu]


Sejnowski TJ, Destexhe A, Mainen Z. (1994). An efficient method for computing synaptic conductances based on a kinetic model of receptor binding Neural Comput. 6

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