Kinetic NMDA receptor model (Kampa et al 2004)

This kinetic NMDA receptor model is based on voltage-clamp recordings of NMDA receptor-mediated currents in nucleated patches of rat neocortical layer 5 pyramidal neurons (Kampa et al 2004 J Physiol), this model was fit with AxoGraph directly to experimental recordings in order to obtain the optimal values for the parameters. The demo shows the behaviour of a kinetic NMDA receptor model reproducing the data in figure 2. The NMDA receptor model uses realistic rates of magnesium block and its effects on channel desensitisation. Presynaptic transmitter release is necessary for glutamate binding to the receptor. This model was written by Bjoern Kampa, Canberra, 2004.

Model Type: Synapse

Cell Type(s): Neocortex L5/6 pyramidal GLU cell

Receptors: NMDA; Glutamate

Transmitters: Glutamate

Model Concept(s): Ion Channel Kinetics; Synaptic Plasticity; Long-term Synaptic Plasticity

Simulation Environment: NEURON

Implementer(s): Kampa, Bjorn M [Bjoern.Kampa at anu.edu.au]

References:

Kampa BM, Clements J, Jonas P, Stuart GJ. (2004). Kinetics of Mg2+ unblock of NMDA receptors: implications for spike-timing dependent synaptic plasticity. The Journal of physiology. 556 [PubMed]