Detailed understanding of IKs gating complexity may provide clues on the mechanisms of cardiac repolarization instability and the resulting arrhythmias. We developed and tested a kinetic Markov model to interpret physiologically relevant IKs properties, including pause-dependency and modulation by beta-adrenergic receptors (beta-AR). The model was developed from the Silva & Rudy formulation. Parameters were optimized on control and ISO experimental data, respectively.
Model Type: Channel/Receptor
Cell Type(s): Cardiac ventricular cell
Simulation Environment: Simulink
Implementer(s): Severi, Stefano [stefano.severi at unibo.it]
Severi S, Corsi C, Rocchetti M, Zaza A. (2009). Mechanisms of beta-adrenergic modulation of I(Ks) in the guinea-pig ventricle: insights from experimental and model-based analysis. Biophysical journal. 96 [PubMed]