Contrast invariance by LGN synaptic depression (Banitt et al. 2007)

"Simple cells in layer 4 of the primary visual cortex of the cat show contrast-invariant orientation tuning, in which the amplitude of the peak response is proportional to the stimulus contrast but the width of the tuning curve hardly changes with contrast. This study uses a detailed model of spiny stellate cells (SSCs) from cat area 17 to explain this property. The model integrates our experimental data, including morphological and intrinsic membrane properties and the number and spatial distribution of four major synaptic input sources of the SSC: the dorsal lateral geniculate nucleus (dLGN) and three cortical sources. ... The model response is in close agreement with experimental results, in terms of both output spikes and membrane voltage (amplitude and fluctuations), with reasonable exceptions given that recurrent connections were not incorporated."

Model Type: Neuron or other electrically excitable cell

Cell Type(s): Neocortex spiny stellate cell

Currents: I Na,t; I A; I K; I K,Ca; I Calcium

Model Concept(s): Pattern Recognition; Activity Patterns; Parameter Fitting; Active Dendrites; Synaptic Integration; Vision

Simulation Environment: NEURON


Banitt Y, Martin KA, Segev I. (2007). A biologically realistic model of contrast invariant orientation tuning by thalamocortical synaptic depression. The Journal of neuroscience : the official journal of the Society for Neuroscience. 27 [PubMed]

Anderson JC, Douglas RJ, Martin KA, Nelson JC. (1994). Map of the synapses formed with the dendrites of spiny stellate neurons of cat visual cortex. The Journal of comparative neurology. 341 [PubMed]

Anderson JC, Douglas RJ, Martin KA, Nelson JC. (1994). Synaptic output of physiologically identified spiny stellate neurons in cat visual cortex. The Journal of comparative neurology. 341 [PubMed]

Banitt Y, Martin KA, Segev I. (2005). Depressed responses of facilitatory synapses. Journal of neurophysiology. 94 [PubMed]

There are 1 other versions of this model. You may select a different one below:

View on GitHub
This website requires cookies and limited processing of your personal data in order to function. By continuing to browse or otherwise use this site, you are agreeing to this use. See our Privacy policy and how to cite and terms of use.