Rat alpha7 nAChR desensitization is modulated by W55 (Gay et al. 2008)


Gay EA, Giniatullin R, Skorinkin A, Yakel JL. (2008). Aromatic residues at position 55 of rat alpha7 nicotinic acetylcholine receptors are critical for maintaining rapid desensitization. The Journal of physiology. 586 [PubMed]

See more from authors: Gay EA · Giniatullin R · Skorinkin A · Yakel JL

References and models cited by this paper

Absalom NL, Lewis TM, Kaplan W, Pierce KD, Schofield PR. (2003). Role of charged residues in coupling ligand binding and channel activation in the extracellular domain of the glycine receptor. The Journal of biological chemistry. 278 [PubMed]

Brejc K et al. (2001). Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors. Nature. 411 [PubMed]

Celie PH et al. (2004). Nicotine and carbamylcholine binding to nicotinic acetylcholine receptors as studied in AChBP crystal structures. Neuron. 41 [PubMed]

Chrétien JM, Chauvet GA. (1998). An algorithmic method for determining the kinetic system of receptor-channel complexes. Mathematical biosciences. 147 [PubMed]

Corringer PJ et al. (1995). Identification of a new component of the agonist binding site of the nicotinic alpha 7 homooligomeric receptor. The Journal of biological chemistry. 270 [PubMed]

Corringer PJ, Le Novère N, Changeux JP. (2000). Nicotinic receptors at the amino acid level. Annual review of pharmacology and toxicology. 40 [PubMed]

Czajkowski C. (2005). Neurobiology: triggers for channel opening. Nature. 438 [PubMed]

Dormand JR, Prince PJ, Baker TS, Gilmore JP. (1996). Continuous approximation with embedded Runge-Kutta methods Appl Numl Math. 22

Fruchart-Gaillard C et al. (2002). Experimentally based model of a complex between a snake toxin and the alpha 7 nicotinic receptor. Proceedings of the National Academy of Sciences of the United States of America. 99 [PubMed]

Gay EA, Bienstock RJ, Lamb PW, Yakel JL. (2007). Structural determinates for apolipoprotein E-derived peptide interaction with the alpha7 nicotinic acetylcholine receptor. Molecular pharmacology. 72 [PubMed]

Gay EA, Klein RC, Yakel JL. (2006). Apolipoprotein E-derived peptides block alpha7 neuronal nicotinic acetylcholine receptors expressed in xenopus oocytes. The Journal of pharmacology and experimental therapeutics. 316 [PubMed]

Gay EA, Yakel JL. (2007). Gating of nicotinic ACh receptors; new insights into structural transitions triggered by agonist binding that induce channel opening. The Journal of physiology. 584 [PubMed]

Giniatullin R, Nistri A, Yakel JL. (2005). Desensitization of nicotinic ACh receptors: shaping cholinergic signaling. Trends in neurosciences. 28 [PubMed]

Hansen SB et al. (2005). Structures of Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces and conformations. The EMBO journal. 24 [PubMed]

Jones S, Sudweeks S, Yakel JL. (1999). Nicotinic receptors in the brain: correlating physiology with function. Trends in neurosciences. 22 [PubMed]

KATZ B, THESLEFF S. (1957). A study of the desensitization produced by acetylcholine at the motor end-plate. The Journal of physiology. 138 [PubMed]

Karlin A, Akabas MH. (1998). Substituted-cysteine accessibility method. Methods in enzymology. 293 [PubMed]

Kash TL, Jenkins A, Kelley JC, Trudell JR, Harrison NL. (2003). Coupling of agonist binding to channel gating in the GABA(A) receptor. Nature. 421 [PubMed]

Kash TL, Kim T, Trudell JR, Harrison NL. (2004). Evaluation of a proposed mechanism of ligand-gated ion channel activation in the GABAA and glycine receptors. Neuroscience letters. 371 [PubMed]

Klein RC, Yakel JL. (2004). Inhibition of nicotinic acetylcholine receptors by apolipoprotein E-derived peptides in rat hippocampal slices. Neuroscience. 127 [PubMed]

Lee WY, Sine SM. (2005). Principal pathway coupling agonist binding to channel gating in nicotinic receptors. Nature. 438 [PubMed]

Lummis SC et al. (2005). Cis-trans isomerization at a proline opens the pore of a neurotransmitter-gated ion channel. Nature. 438 [PubMed]

Mercado J, Czajkowski C. (2006). Charged residues in the alpha1 and beta2 pre-M1 regions involved in GABAA receptor activation. The Journal of neuroscience : the official journal of the Society for Neuroscience. 26 [PubMed]

Mike A, Castro NG, Albuquerque EX. (2000). Choline and acetylcholine have similar kinetic properties of activation and desensitization on the alpha7 nicotinic receptors in rat hippocampal neurons. Brain research. 882 [PubMed]

Papke RL, Porter Papke JK. (2002). Comparative pharmacology of rat and human alpha7 nAChR conducted with net charge analysis. British journal of pharmacology. 137 [PubMed]

Paradiso KG, Steinbach JH. (2003). Nicotine is highly effective at producing desensitization of rat alpha4beta2 neuronal nicotinic receptors. The Journal of physiology. 553 [PubMed]

Quick MW, Lester RA. (2002). Desensitization of neuronal nicotinic receptors. Journal of neurobiology. 53 [PubMed]

Reeves DC, Jansen M, Bali M, Lemster T, Akabas MH. (2005). A role for the beta 1-beta 2 loop in the gating of 5-HT3 receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. 25 [PubMed]

Schofield CM, Trudell JR, Harrison NL. (2004). Alanine-scanning mutagenesis in the signature disulfide loop of the glycine receptor alpha 1 subunit: critical residues for activation and modulation. Biochemistry. 43 [PubMed]

Sine SM, Engel AG. (2006). Recent advances in Cys-loop receptor structure and function. Nature. 440 [PubMed]

Smit AB et al. (2001). A glia-derived acetylcholine-binding protein that modulates synaptic transmission. Nature. 411 [PubMed]

Spier AD, Lummis SC. (2000). The role of tryptophan residues in the 5-Hydroxytryptamine(3) receptor ligand binding domain. The Journal of biological chemistry. 275 [PubMed]

Unwin N. (2005). Refined structure of the nicotinic acetylcholine receptor at 4A resolution. Journal of molecular biology. 346 [PubMed]

Xie Y, Cohen JB. (2001). Contributions of Torpedo nicotinic acetylcholine receptor gamma Trp-55 and delta Trp-57 to agonist and competitive antagonist function. The Journal of biological chemistry. 276 [PubMed]

Xiu X, Hanek AP, Wang J, Lester HA, Dougherty DA. (2005). A unified view of the role of electrostatic interactions in modulating the gating of Cys loop receptors. The Journal of biological chemistry. 280 [PubMed]

Young GT et al. (2007). Species selectivity of a nicotinic acetylcholine receptor agonist is conferred by two adjacent extracellular beta4 amino acids that are implicated in the coupling of binding to channel gating. Molecular pharmacology. 71 [PubMed]

References and models that cite this paper
This website requires cookies and limited processing of your personal data in order to function. By continuing to browse or otherwise use this site, you are agreeing to this use. See our Privacy policy and how to cite and terms of use.