In this paper, the model was used to show how the temporal summation of excitatory inputs in CA3 pyramidal neurons was affected by the presence of Ih in the dendrites in a frequency- and distance-dependent fashion.
Model Type: Dendrite
Region(s) or Organism(s): Hippocampus
Cell Type(s): Hippocampus CA3 pyramidal GLU cell
Currents: I h
Receptors: AMPA
Transmitters: Glutamate
Model Concept(s): Synaptic Integration
Simulation Environment: NEURON
Implementer(s): Migliore, Michele [Michele.Migliore at Yale.edu]
References:
Hemond P, Migliore M, Ascoli GA, Jaffe DB. (2009). The membrane response of hippocampal CA3b pyramidal neurons near rest: Heterogeneity of passive properties and the contribution of hyperpolarization-activated currents. Neuroscience. 160 [PubMed]