This model simulates different phases of LTP/D, i.e. the induction or early phase, the setting of synaptic tags, a trigger process for protein synthesis, and a slow transition leading to synaptic consolidation namely the late phase of synaptic plasticity. The model explains a large body of experimental data on synaptic tagging and capture, cross-tagging, and the late phases of LTP and LTD. Moreover, the model accounts for the dependence of LTP and LTD induction on voltage and presynaptic stimulation frequency.
Model Type: Neuron or other electrically excitable cell; Synapse
Cell Type(s): Hippocampus CA1 pyramidal GLU cell; Abstract integrate-and-fire adaptive exponential (AdEx) neuron
Transmitters: Dopamine
Model Concept(s): Simplified Models; Synaptic Plasticity; Long-term Synaptic Plasticity; Maintenance
Simulation Environment: Python
Implementer(s): Ziegler, Lorric
References:
Clopath C, Ziegler L, Vasilaki E, Büsing L, Gerstner W. (2008). Tag-trigger-consolidation: a model of early and late long-term-potentiation and depression. PLoS computational biology. 4 [PubMed]