A network model of the vertebrate retina (Publio et al. 2009)


In this work, we use a minimal conductance-based model of the ON rod pathways in the vertebrate retina to study the effects of electrical synaptic coupling via gap junctions among rods and among AII amacrine cells on the dynamic range of the retina. The model is also used to study the effects of the maximum conductance of rod hyperpolarization activated current Ih on the dynamic range of the retina, allowing a study of the interrelations between this intrinsic membrane parameter with those two retina connectivity characteristics.

Model Type: Realistic Network

Cell Type(s): Retina ganglion GLU cell; Retina photoreceptor cone GLU cell; Retina bipolar GLU cell

Transmitters: Glutamate

Model Concept(s): Sensory processing

Simulation Environment: NEURON

Implementer(s): Publio, Rodrigo [publio at oist.jp]

References:

Publio R, Oliveira RF, Roque AC. (2009). A computational study on the role of gap junctions and rod Ih conductance in the enhancement of the dynamic range of the retina. PloS one. 4 [PubMed]

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