Huntington`s disease model (Gambazzi et al. 2010)


Gambazzi L et al. (2010). Diminished activity-dependent brain-derived neurotrophic factor expression underlies cortical neuron microcircuit hypoconnectivity resulting from exposure to mutant huntingtin fragments. The Journal of pharmacology and experimental therapeutics. 335 [PubMed]

See more from authors: Gambazzi L · Gokce O · Seredenina T · Katsyuba E · Runne H · Markram H · Giugliano M · Luthi-Carter R

References and models cited by this paper

Aid T, Kazantseva A, Piirsoo M, Palm K, Timmusk T. (2007). Mouse and rat BDNF gene structure and expression revisited. Journal of neuroscience research. 85 [PubMed]

Benn CL, Fox H, Bates GP. (2008). Optimisation of region-specific reference gene selection and relative gene expression analysis methods for pre-clinical trials of Huntington's disease. Molecular neurodegeneration. 3 [PubMed]

Bezprozvanny I. (2007). Inositol 1,4,5-tripshosphate receptor, calcium signalling and Huntington's disease. Sub-cellular biochemistry. 45 [PubMed]

Cepeda C et al. (2004). Increased GABAergic function in mouse models of Huntington's disease: reversal by BDNF. Journal of neuroscience research. 78 [PubMed]

Cepeda C, Wu N, André VM, Cummings DM, Levine MS. (2007). The corticostriatal pathway in Huntington's disease. Progress in neurobiology. 81 [PubMed]

Chen WG et al. (2003). Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2. Science (New York, N.Y.). 302 [PubMed]

Cummings DM et al. (2009). Alterations in cortical excitation and inhibition in genetic mouse models of Huntington's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. 29 [PubMed]

Fan MM, Raymond LA. (2007). N-methyl-D-aspartate (NMDA) receptor function and excitotoxicity in Huntington's disease. Progress in neurobiology. 81 [PubMed]

Gharami K, Xie Y, An JJ, Tonegawa S, Xu B. (2008). Brain-derived neurotrophic factor over-expression in the forebrain ameliorates Huntington's disease phenotypes in mice. Journal of neurochemistry. 105 [PubMed]

Giralt A et al. (2009). Brain-derived neurotrophic factor modulates the severity of cognitive alterations induced by mutant huntingtin: involvement of phospholipaseCgamma activity and glutamate receptor expression. Neuroscience. 158 [PubMed]

Giugliano M, La Camera G, Fusi S, Senn W. (2008). The response of cortical neurons to in vivo-like input current: theory and experiment: II. Time-varying and spatially distributed inputs. Biological cybernetics. 99 [PubMed]

Greer PL, Greenberg ME. (2008). From synapse to nucleus: calcium-dependent gene transcription in the control of synapse development and function. Neuron. 59 [PubMed]

Heitz F, La Rosa S, Gonzalez-Couto E, Gaviraghi G, Terstappen GC. (2008). Drug discovery and development for Huntington's disease - an orphan indication with high medical need. IDrugs : the investigational drugs journal. 11 [PubMed]

Hodges A et al. (2006). Regional and cellular gene expression changes in human Huntington's disease brain. Human molecular genetics. 15 [PubMed]

Hong EJ, McCord AE, Greenberg ME. (2008). A biological function for the neuronal activity-dependent component of Bdnf transcription in the development of cortical inhibition. Neuron. 60 [PubMed]

Jones L, Harper P, Bates GP. (2002). Huntington`s Disease. 3rd ed

Kagan BL, Hirakura Y, Azimov R, Azimova R. (2001). The channel hypothesis of Huntington's disease. Brain research bulletin. 56 [PubMed]

Kobayashi H et al. (2008). Expression changes of multiple brain-derived neurotrophic factor transcripts in selective spinal nerve ligation model and complete Freund's adjuvant model. Brain research. 1206 [PubMed]

La Camera G, Giugliano M, Senn W, Fusi S. (2008). The response of cortical neurons to in vivo-like input current: theory and experiment : I. Noisy inputs with stationary statistics. Biological cybernetics. 99 [PubMed]

Luthi-Carter R et al. (2003). Complex alteration of NMDA receptors in transgenic Huntington's disease mouse brain: analysis of mRNA and protein expression, plasma membrane association, interacting proteins, and phosphorylation. Neurobiology of disease. 14 [PubMed]

Luthi-carter R. (2007). Huntington`s and other polyglutamine diseases: many effects of single gene mutations Drug Discov Today Dis Mech. 4

Lynch G et al. (2007). Brain-derived neurotrophic factor restores synaptic plasticity in a knock-in mouse model of Huntington's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. 27 [PubMed]

Marom S, Shahaf G. (2002). Development, learning and memory in large random networks of cortical neurons: lessons beyond anatomy. Quarterly reviews of biophysics. 35 [PubMed]

Miyashita T et al. (2005). Interference with activity-dependent transcriptional activation of BDNF gene depending upon the expanded polyglutamines in neurons. Biochemical and biophysical research communications. 333 [PubMed]

Morton AJ, Edwardson JM. (2001). Progressive depletion of complexin II in a transgenic mouse model of Huntington's disease. Journal of neurochemistry. 76 [PubMed]

Nakata H, Nakamura S. (2007). Brain-derived neurotrophic factor regulates AMPA receptor trafficking to post-synaptic densities via IP3R and TRPC calcium signaling. FEBS letters. 581 [PubMed]

Oyama F et al. (2006). Sodium channel beta4 subunit: down-regulation and possible involvement in neuritic degeneration in Huntington's disease transgenic mice. Journal of neurochemistry. 98 [PubMed]

Perkel DH, Gerstein GL, Moore GP. (1967). Neuronal spike trains and stochastic point processes. II. Simultaneous spike trains. Biophysical journal. 7 [PubMed]

Potter SM, DeMarse TB. (2001). A new approach to neural cell culture for long-term studies. Journal of neuroscience methods. 110 [PubMed]

Pruunsild P, Kazantseva A, Aid T, Palm K, Timmusk T. (2007). Dissecting the human BDNF locus: bidirectional transcription, complex splicing, and multiple promoters. Genomics. 90 [PubMed]

Rosas HD et al. (2010). Altered white matter microstructure in the corpus callosum in Huntington's disease: implications for cortical "disconnection". NeuroImage. 49 [PubMed]

Rosas HD et al. (2008). Cerebral cortex and the clinical expression of Huntington's disease: complexity and heterogeneity. Brain : a journal of neurology. 131 [PubMed]

Rudinskiy N et al. (2009). Diminished hippocalcin expression in Huntington's disease brain does not account for increased striatal neuron vulnerability as assessed in primary neurons. Journal of neurochemistry. 111 [PubMed]

Régulier E, Trottier Y, Perrin V, Aebischer P, Déglon N. (2003). Early and reversible neuropathology induced by tetracycline-regulated lentiviral overexpression of mutant huntingtin in rat striatum. Human molecular genetics. 12 [PubMed]

Sakata K et al. (2009). Critical role of promoter IV-driven BDNF transcription in GABAergic transmission and synaptic plasticity in the prefrontal cortex. Proceedings of the National Academy of Sciences of the United States of America. 106 [PubMed]

Smith R et al. (2007). Loss of SNAP-25 and rabphilin 3a in sensory-motor cortex in Huntington's disease. Journal of neurochemistry. 103 [PubMed]

Thu DC et al. (2010). Cell loss in the motor and cingulate cortex correlates with symptomatology in Huntington's disease. Brain : a journal of neurology. 133 [PubMed]

Van Den Pol AN, Obrietan K, Belousov A. (1996). Glutamate hyperexcitability and seizure-like activity throughout the brain and spinal cord upon relief from chronic glutamate receptor blockade in culture. Neuroscience. 74 [PubMed]

Walker AG, Miller BR, Fritsch JN, Barton SJ, Rebec GV. (2008). Altered information processing in the prefrontal cortex of Huntington's disease mouse models. The Journal of neuroscience : the official journal of the Society for Neuroscience. 28 [PubMed]

Yoshii A, Constantine-Paton M. (2007). BDNF induces transport of PSD-95 to dendrites through PI3K-AKT signaling after NMDA receptor activation. Nature neuroscience. 10 [PubMed]

Zala D et al. (2005). Progressive and selective striatal degeneration in primary neuronal cultures using lentiviral vector coding for a mutant huntingtin fragment. Neurobiology of disease. 20 [PubMed]

Zuccato C, Cattaneo E. (2007). Role of brain-derived neurotrophic factor in Huntington's disease. Progress in neurobiology. 81 [PubMed]

Zuccato C et al. (2008). Systematic assessment of BDNF and its receptor levels in human cortices affected by Huntington's disease. Brain pathology (Zurich, Switzerland). 18 [PubMed]

Zucker B et al. (2005). Transcriptional dysregulation in striatal projection- and interneurons in a mouse model of Huntington's disease: neuronal selectivity and potential neuroprotective role of HAP1. Human molecular genetics. 14 [PubMed]

van Pelt J, Wolters PS, Corner MA, Rutten WL, Ramakers GJ. (2004). Long-term characterization of firing dynamics of spontaneous bursts in cultured neural networks. IEEE transactions on bio-medical engineering. 51 [PubMed]

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