One of the cellular mechanisms underlying the generation of gamma oscillations is a type of cortical pyramidal neuron named fast rhythmic bursting (FRB) cells. After cells from cats' primary visual cortices were filled with Neurobiotin, the brains were cut, and the cells were photographed. One FRB cell was chosen to be confocaled, reconstructed with Neurolucida software, and generated a detailed multi-compartmental model in the NEURON program. We explore firing properties of FRB cells and the role of enhanced Na+ conductance.
Model Type: Neuron or other electrically excitable cell
Region(s) or Organism(s): Neocortex
Currents: I Na,p; I Na,t; I K,Ca; I Sodium; I Calcium; I Potassium; I_Na,Ca; I_K,Na
Transmitters: Glutamate
Model Concept(s): Activity Patterns; Bursting; Spatio-temporal Activity Patterns; Action Potentials; Vision
Simulation Environment: NEURON
Implementer(s): Lee, Jin [jin3 at sas.upenn.edu]
References:
Lee J. (2007). Fast Rhythmic Bursting Cells: The Horizontal Fiber System in the Cat’s Primary Visual Cortex Penn McNair Research Journal. 1(1)