A two-stage model of dendritic integration in CA1 pyramidal neurons (Katz et al. 2009)

"... In a two-stage integration model, inputs contribute directly to dendritic spikes, and outputs from multiple branches sum in the axon. ... We used serial-section electron microscopy to reconstruct individual apical oblique dendritic branches of CA1 pyramidal neurons and observe a synapse distribution consistent with the two-stage integration model. Computational modeling suggests that the observed synapse distribution enhances the contribution of each dendritic branch to neuronal output."

Model Type: Neuron or other electrically excitable cell

Region(s) or Organism(s): Hippocampus

Cell Type(s): Hippocampus CA1 pyramidal GLU cell

Currents: I Na,t; I A; I K

Model Concept(s): Synaptic Integration

Simulation Environment: NEURON (web link to model)

References:

Katz Y et al. (2009). Synapse distribution suggests a two-stage model of dendritic integration in CA1 pyramidal neurons. Neuron. 63 [PubMed]