Comparison of full and reduced globus pallidus models (Hendrickson 2010)

In this paper, we studied what features of realistic full model activity patterns can and cannot be preserved by morphologically reduced models. To this end, we reduced the morphological complexity of a full globus pallidus neuron model possessing active dendrites and compared its spontaneous and driven responses to those of the reduced models.

Model Type: Neuron or other electrically excitable cell

Cell Type(s): Globus pallidus neuron

Currents: I Na,p; I A; I K; I K,Ca; I Calcium; I A, slow

Receptors: AMPA; NMDA; Gaba

Transmitters: Gaba; Glutamate

Model Concept(s): Activity Patterns; Simplified Models; Active Dendrites; Action Potentials; Methods; Rate-coding model neurons; Synaptic Integration

Simulation Environment: GENESIS

Implementer(s): Hendrickson, Eric B [eric.b.hendrickson at]


Hendrickson EB, Edgerton JR, Jaeger D. (2011). The capabilities and limitations of conductance-based compartmental neuron models with reduced branched or unbranched morphologies and active dendrites. Journal of computational neuroscience. 30 [PubMed]

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