Short term plasticity at the cerebellar granule cell (Nieus et al. 2006)

The model reproduces short term plasticity of the mossy fibre to granule cell synapse. To reproduce synaptic currents recorded in experiments, a model of presynaptic release was used to determine the concentration of glutamate in the synaptic cleft that ultimately determined a synaptic response. The parameters of facilitation and depression were determined deconvolving AMPA EPSCs.

Model Type: Synapse

Cell Type(s): Cerebellum interneuron granule GLU cell

Receptors: AMPA; NMDA

Transmitters: Glutamate

Model Concept(s): Short-term Synaptic Plasticity

Simulation Environment: NEURON

Implementer(s): Nieus, Thierry [thierry.nieus at iit.it]

References:

Nieus T et al. (2006). LTP regulates burst initiation and frequency at mossy fiber-granule cell synapses of rat cerebellum: experimental observations and theoretical predictions. Journal of neurophysiology. 95 [PubMed]