The model reproduces short term plasticity of the mossy fibre to granule cell synapse. To reproduce synaptic currents recorded in experiments, a model of presynaptic release was used to determine the concentration of glutamate in the synaptic cleft that ultimately determined a synaptic response. The parameters of facilitation and depression were determined deconvolving AMPA EPSCs.
Model Type: Synapse
Cell Type(s): Cerebellum interneuron granule GLU cell
Model Concept(s): Short-term Synaptic Plasticity
Simulation Environment: NEURON
Implementer(s): Nieus, Thierry [thierry.nieus at iit.it]
Nieus T et al. (2006). LTP regulates burst initiation and frequency at mossy fiber-granule cell synapses of rat cerebellum: experimental observations and theoretical predictions. Journal of neurophysiology. 95 [PubMed]