"After a meal, the gastrointestinal tract exhibits a set of behaviours known as the fed state. ... Segmentation manifests as rhythmic local constrictions that do not propagate along the intestine. ... We investigated the enteric circuits that regulate segmentation focusing on a central feature of the ENS: a recurrent excitatory network of intrinsic sensory neurons (ISNs) which are characterized by prolonged after-hyperpolarizing potentials (AHPs) following their action potentials. ..."
Model Type: Realistic Network; Neural mass
Model Concept(s): Activity Patterns
Simulation Environment: MATLAB; Simulink
Implementer(s): Chambers, Jordan [jordandchambers at gmail.com]
References:
Thomas EA, Bornstein JC, Chambers JD. (2011). Multiple Neural Oscillators and Muscle Feedback Are Required for the Intestinal Fed State Motor Program PLoS ONE. 6(5)