Collection of XPP (.ode) files simulating the signal transduction (slow) and action potential (fast) currents in the olfactory receptor neuron of mouse. Collection contains model configured for dual odorant pulse delivery and model configured for prolonged odorant delivery. For those interested more in transduction processes, each whole cell recording model comes with a counter part file configured to show just the slow transduction current for ease of use and convenience. These transduction-only models typically run faster than the full multi-scale models but do not demonstrate action potentials.
Model Type: Neuron or other electrically excitable cell; Axon; Dendrite
Cell Type(s): Olfactory receptor GLU cell
Currents: I K; I Cl,Ca; I CNG; Na/Ca exchanger; I_Na,Ca; I_K,Na; I ANO2
Transmitters: Ions
Model Concept(s): Action Potential Initiation; Oscillations; Parameter Fitting; Simplified Models; Axonal Action Potentials; Action Potentials; Signaling pathways; G-protein coupled; Multiscale; Olfaction
Simulation Environment: XPPAUT
Implementer(s): Dougherty, Daniel P [dpdoughe at mbi.ohio-state.edu]
References:
Dougherty DP. (2009). Workshop: Computational Problems in Sequential Stages of Odor Processing. Modeling Diversity in the Signal Transduction of the Mouse Olfactory Receptor Neuron. Abstracts from the Thirty-first Annual Meeting of the Association for Chemoreception Sciences. AChemS