Myelinated nerve fibre myelin resistance dependent on extracellular K+ level (Brazhe et al. 2010)

Excitation leads to rise in paranodal [K]e under the myelin. This causes structural changes in myelin structure and resistance. Current model aims to simulate this aspect. This is a space-clamped model of a double-cable nerve fibre.

Model Type: Extracellular

Cell Type(s): Myelinated neuron

Currents: I Na,p; I Na,t; I K; I K,leak; I_Ks; Na/K pump

Model Concept(s): Intermittent block

Simulation Environment: Lua

Implementer(s): Brazhe, Alexey [brazhe at]


Mosekilde E, Brazhe AR, Maksimov GV, Sosnovtseva O. (2010). Excitation block in a nerve fibre model owing to potassium-dependent changes in myelin resistance Journal of Interface Focus. 1(1)

This website requires cookies and limited processing of your personal data in order to function. By continuing to browse or otherwise use this site, you are agreeing to this use. See our Privacy policy and how to cite and terms of use.