Myelinated nerve fibre myelin resistance dependent on extracellular K+ level (Brazhe et al. 2010)

Excitation leads to rise in paranodal [K]e under the myelin. This causes structural changes in myelin structure and resistance. Current model aims to simulate this aspect. This is a space-clamped model of a double-cable nerve fibre.

Model Type: Extracellular

Cell Type(s): Myelinated neuron

Currents: I Na,p; I Na,t; I K; I K,leak; I_Ks; Na/K pump

Model Concept(s): Intermittent block

Simulation Environment: Lua

Implementer(s): Brazhe, Alexey [brazhe at gmail.com]

References:

Mosekilde E, Brazhe AR, Maksimov GV, Sosnovtseva O. (2010). Excitation block in a nerve fibre model owing to potassium-dependent changes in myelin resistance Journal of Interface Focus. 1(1)