HMM of Nav1.7 WT and F1449V (Gurkiewicz et al. 2011)

Neuron mod files for the WT and F1449V Na+ currents from the paper: Kinetic Modeling of Nav1.7 Provides Insight Into Erythromelalgia-associated F1449V Mutation M. Gurkiewicz, A. Korngreen, S. Waxman, and A. Lampert. J.Neurophysiol. (2011). The parameters for the K65, K53 and K63 transitions were derived from microscopic reversibility relationships in the model.

Model Type: Channel/Receptor

Cell Type(s): Dorsal Root Ganglion (DRG) cell

Currents: I Sodium

Genes: Nav1.7 SCN9A

Model Concept(s): Nociception; Erythromelalgia

Simulation Environment: NEURON

Implementer(s): Gurkiewicz, Meron [gurkiewicz at gmail.com]

References:

Gurkiewicz M, Korngreen A, Waxman SG, Lampert A. (2011). Kinetic modeling of Nav1.7 provides insight into erythromelalgia-associated F1449V mutation. Journal of neurophysiology. 105 [PubMed]